HRID421972
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
A solution of the crude tert-butyl {2-[{[6-({benzyl[(3-chloropropyl)sulfonyl]amino}carbonyl)-3-cyclohexyl-2-phenyl-1H-indol-1-yl]acetyl}(methyl)amino]ethyl}methylcarbamate in DCM) (0.09 M) was treated with TFA (140 eq) at 0° C. The reaction was allowed to reach RT in about 1 h. The solvent was then removed in vacuo, a 2 M solution HCl in Et2O was added and the volatiles removed in vacuo. MeCN was added and the precipitate was collected by filtration to afford clean compound (30%). (ES+) m/z 677 (M+H)+
WORKUP
后处理
- customThe solvent was then removed in vacuo
- additiona 2 M solution HCl in Et2O was added
- customthe volatiles removed in vacuo
- additionMeCN was added
- filtrationthe precipitate was collected by filtration