反应详情

The mixture of 430 mg of methyl 3-chloro-2-cyanobenzoic acid obtained by the same manner as in U.S. Pat. No. 4,900,739, 22 ml of methanol and 2.5 ml of aqueous sodium hydroxide (1 mol/l) was stirring at room temperature for 2 hours. To the reaction mixture was added hydrochloride (5 mol/l) and was extracted with chloroform. The organic layer was washed with water and saturated brine, and then dried over magnesium sulfate. The organic layer was filtered and concentrated in vacuo to give the title compound.

1. customobtained by the same manner as in U.S
2. extractionwas extracted with chloroform
3. washThe organic layer was washed with water and saturated brine
4. dry with materialdried over magnesium sulfate
5. filtrationThe organic layer was filtered
6. concentrationconcentrated in vacuo