HCID 59804275, compound → HCID 59804376, compound

Participants

Reaction Steps

A solution of 2-[2-nitro-5-(3-nitro-phenylamino)-phenyl]-malonic acid dimethyl ester (0.68 g, 1.7 mmol) in 6 N hydrochloric acid (20 ml) is heated at 110° C. for 10 hours. It is then cooled to room temperature and the mixture is extracted with ethyl acetate (100 ml×3). The organic layers are combined, dried, concentrated to give crude [2-nitro-5-(3-nitro-phenylamino)-phenyl]-acetic acid: LC-MS: 318.0 (MH+).

Provenance & Evidence