HCID 59804275, compound → HCID 59804376, compound

HRID 422025Notes

Reaction equation

HRID 422025 reaction equation
C[O:2][C:3](=[O:28])[CH:4]([C:9]1[CH:14]=[C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)[CH:12]=[CH:11][C:10]=1[N+:25]([O-:27])=[O:26])C(OC)=O>Cl>[N+:25]([C:10]1[CH:11]=[CH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)=[CH:14][C:9]=1[CH2:4][C:3]([OH:28])=[O:2])([O-:27])=[O:26]

Participants

3

Reactant 1

HCID 59804275HCID 59804275, compound

Product 1

HCID 59804376HCID 59804376, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 2-[2-nitro-5-(3-nitro-phenylamino)-phenyl]-malonic acid dimethyl ester (0.68 g, 1.7 mmol) in 6 N hydrochloric acid (20 ml) is heated at 110° C. for 10 hours. It is then cooled to room temperature and the mixture is extracted with ethyl acetate (100 ml×3). The organic layers are combined, dried, concentrated to give crude [2-nitro-5-(3-nitro-phenylamino)-phenyl]-acetic acid: LC-MS: 318.0 (MH+).

Workup

  1. extractionthe mixture is extracted with ethyl acetate (100 ml×3)
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-bf7cb1c16d2c49c1a42e0914bbd01bf4
Source dataset
uspto-grants-2012_01
Patent number
US08101608B2

Reaction notes

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