HCID 59804293, compound → HCID 59804362, compound

HRID 422027Notes

Reaction equation

HRID 422027 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:11]=[C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=2)[CH:9]=[CH:8][C:7]=1[N+:22]([O-])=O)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:11]=[C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[CH:14]=2)[CH:9]=[CH:8][C:7]=1[NH2:22])[CH3:2]

Participants

4

Reactant 1

HCID 59804293HCID 59804293, compound

Product 1

HCID 59804362HCID 59804362, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of [2-nitro-5-(3-nitro-phenylamino)-phenyl]-acetic acid ethyl ester (0.36 g, 1.0 mmol) in methanol (10 ml) is added Pd/C (10%, wet, 0.1 g). The reaction is placed under a hydrogen balloon and stirred for 20 hours. The catalyst is filtered and the solvent is removed to give the desired compound. LC-MS: 286.1 (MH+).

Workup

  1. filtrationThe catalyst is filtered
  2. customthe solvent is removed

Sources & evidence

ORD record
ord-f19e19ac5cc6404d807670efe283fc57
Source dataset
uspto-grants-2012_01
Patent number
US08101608B2

Reaction notes

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