反应详情

A mixture of 336 mg of methyl 2-(3-chlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate which was synthesized in Production Example 1, 3.0 mL of aqueous 1N sodium hydroxide solution and 6 mL of ethanol was heated for 2.5 hours under reflux. The reaction solution was allowed to cool off, and to which 3.0 mL of 1N hydrochloric acid and 5 mL of water were added. Whereupon precipitated crystals were recovered by filtration, washed with water and through-flow dried under heating, to provide 300 mg of the title compound.

1. temperaturewas heated for 2.5 hours
2. temperatureunder reflux
3. temperatureto cool off
4. customWhereupon precipitated crystals
5. filtrationwere recovered by filtration
6. washwashed with water
7. customthrough-flow dried
8. temperatureunder heating