Acetophenone → HCID 86633655, compound

HRID 422044Notes

Reaction equation

HRID 422044 reaction equation
FC1C=CC([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:11][C:10](=[O:20])[N:9]=2)=CC=1C.C(C1C=CC=CC=1)(=O)C.COCCOC1C=CC=CC=1C(OC)=O.[F:46][C:47]1[CH:55]=[CH:54][C:50](C(O)=O)=[CH:49][C:48]=1[CH3:56]>>[F:46][C:47]1[CH:55]=[CH:54][C:50]([N:11]2[C:12]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:13][CH:8]=[N:9][C:10]2=[O:20])=[CH:49][C:48]=1[CH3:56]

Participants

5

Reactant 4

HCID 7410AcetophenoneHCID 2428284-Fluoro-3-methylbenzoic acidHCID 166606614-(4-fluoro-3-methylphenyl)-6-phenylpyrimidin-2(1H)-oneHCID 22381872Methyl 2-(2-methoxyethoxy)benzoate

Product 1

HCID 86633655HCID 86633655, compound

Procedure

Using the same or analogous synthetic techniques described in Example 1, 4-(4-fluoro-3-methylphenyl)-6-phenylpyrimidin-2(1H)-one was prepared by replacing 1-[(4-hydroxy-3-methyl)phenyl]ethanone with commercially available acetophenone and methyl 2-{[2-(methyloxy)ethyl]oxy}benzoate with commercially available 4-fluoro-3-methylbenzoic acid.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-4ece72248d834bc68264202605078eec
Source dataset
uspto-grants-2012_01
Patent number
US08101625B2

Reaction notes

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