2,3-Dichlorobenzaldehyde → 4-(4-Hydroxy-3-methylphenyl)-6-[2-(1-methylethyl)phenyl]pyrimidin

HRID 422067Notes

Reaction equation

HRID 422067 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH:20]([CH3:22])[CH3:21])[NH:11][C:10](=O)[N:9]=2)=[CH:4][C:3]=1[CH3:24].ClC1C(Cl)=CC=CC=1C=O.C(C1C=CC=CC=1C=O)(C)C>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH:20]([CH3:21])[CH3:22])[N:11]=[CH:10][N:9]=2)=[CH:4][C:3]=1[CH3:24]

Participants

4

Reactant 3

HCID 357452,3-DichlorobenzaldehydeHCID 5905362-(Propan-2-yl)benzaldehydeHCID 1355898614-(4-hydroxy-3-methylphenyl)-6-[2-(1-methylethyl)phenyl]pyrimidin-2(1H)-one

Product 1

HCID 1363568084-(4-Hydroxy-3-methylphenyl)-6-[2-(1-methylethyl)phenyl]pyrimidin

Procedure

Using the same or analogous synthetic techniques described in Example 68, 4-(4-hydroxy-3-methylphenyl)-6-[2-(1-methylethyl)phenyl]pyrimidin-2(1H)-one was prepared by replacing 2,3-dichlorobenzaldehyde with commercially available 2-isopropylbenzaldehyde.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-5ae823fd763547d3b700ea1f030fb04a
Source dataset
uspto-grants-2012_01
Patent number
US08101625B2

Reaction notes

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