HCID 25017037, compound → HCID 66672330, compound

HRID 422078Notes

Reaction equation

HRID 422078 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:16][C:15]3[CH:14]=[CH:13][N:12]([C:17]4[CH:18]=[C:19]5[C:23](=[CH:24][CH:25]=4)[N:22]([CH2:26][CH2:27][N:28]4[CH2:32][CH2:31][C@@H:30]([OH:33])[CH2:29]4)[N:21]=[CH:20]5)[C:11](=[O:34])[C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.O1C2C(C(=O)N=CC=2)=CC1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:16][C:15]3[CH:14]=[CH:13][N:12]([C:17]4[CH:18]=[C:19]5[C:23](=[CH:24][CH:25]=4)[N:22]([CH2:26][CH2:27][N:28]4[CH2:32][CH2:31][C@@H:30]([OH:33])[CH2:29]4)[N:21]=[CH:20]5)[C:11](=[O:34])[C:10]=3[CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 25017037HCID 25017037, compoundHCID 86637281HCID 86637281, compound

Product 1

HCID 66672330HCID 66672330, compound

Procedure

Following the procedure of Example 3, but substituting (R)-2-(4-chlorophenyl)-5-(1-(2-(3-hydroxypyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridine-4-one for the (R)-2-(4-chlorophenyl)-5-(1-(2-(2-hydroxymethyl)pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridine-4-one, the title compound (22.2 mg, quantitative) was prepared as an off-white solid: mp 242-246° C. (decomposition); ESI MS m/z 475 [M+H]+; HPLC (Method A) 97.6% (AUC), tR=15.4 min.

Sources & evidence

ORD record
ord-21de86920a03403ab364073dea8deb03
Source dataset
uspto-grants-2012_01
Patent number
US08101632B2

Reaction notes

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