Acetic Anhydride → HCID 59240564, compound

HRID 42215Notes

Reaction equation

HRID 42215 reaction equation
[CH2:1]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[N:29]=[CH:28][C:27]([NH2:30])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[N:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31](OC(=O)C)(=[O:33])[CH3:32]>>[CH2:1]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([N:18]2[CH2:19][CH2:20][N:21]([C:24]3[N:25]=[CH:26][C:27]([NH:30][C:31](=[O:33])[CH3:32])=[CH:28][N:29]=3)[CH2:22][CH2:23]2)=[N:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 592405782-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyrimidin-5-ylamine

Product 1

HCID 59240564HCID 59240564, compoundYield 31.9%

Procedure

Following the above procedure, 2-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyrimidin-5-ylamine (60 mg, 0.15 mmol) and acetic anhydride (22.2 μL, 0.235 mmol) afford the title compound (21 mg, 31%).

Sources & evidence

ORD record
ord-ef8fd8292a4f416282afbb4b84638556
Source dataset
uspto-grants-2013_09
Patent number
US08536168B2

Reaction notes

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