Potassium Carbonate → HCID 59750692, compound

HRID 422194Notes

Reaction equation

HRID 422194 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12].Cl[C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][N:15]=1.C([O-])([O-])=O.[K+].[K+]>>[O:1]=[C:2]1[CH2:11][CH2:10][CH2:9][C:8]2[C:7]([O:12][C:14]3[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][N:15]=3)=[CH:6][CH:5]=[CH:4][C:3]1=2

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 804566-ChloronicotinamideHCID 1199215-Hydroxy-1-tetralone

Product 1

HCID 59750692HCID 59750692, compoundYield 55.3%

Procedure

Using a method similar to Intermediate 1, using 5-hydroxy-1-tetralone (2.68 g, 16.5 mmol), 6-chloronicotinamide (2.34 g, 15.0 mmol) and K2CO3 (3.11 g, 22.5 mmol) gives the title compound (2.34 g) as a yellow solid. Mass spectrum (ion spray): m/z=283 (M+1); 1HNMR (DMSO-d6): 8.55 (s, 1H), 8.27 (d, 1H), 8.02 (s, 113), 7.80 (m, 1H), 7.48 (s, 1H), 7.43-7.37 (m, 1H), 7.14 (d, 1H), 2.66 (t, 2H), 2.58 (t, 2H), 1.96 (m, 2H).

Sources & evidence

ORD record
ord-e55ab314a6804512a0bdf3134e77a1d5
Source dataset
uspto-grants-2012_01
Patent number
US08101638B2

Reaction notes

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