Potassium Carbonate → HCID 59750677, compound

HRID 422196Notes

Reaction equation

HRID 422196 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:11].Cl[C:13]1[CH:21]=[CH:20][C:16]([C:17]([NH2:19])=[O:18])=[CH:15][N:14]=1.C([O-])([O-])=O.[K+].[K+]>>[O:11]=[C:6]1[C:7]2[C:3](=[C:2]([O:1][C:13]3[CH:21]=[CH:20][C:16]([C:17]([NH2:19])=[O:18])=[CH:15][N:14]=3)[CH:10]=[CH:9][CH:8]=2)[CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 804566-ChloronicotinamideHCID 5905474-Hydroxy-1-indanone

Product 1

HCID 59750677HCID 59750677, compoundYield 30.3%

Procedure

Using a method similar to Intermediate 1, using 4-hydroxy-1-indanone (2.44 g, 16.5 mmol), 6-chloronicotinamide (234 g, 15.0 mmol) and K2CO3 (3.11 g, 22.5 mmol) gives the title compound (1.22 g) as a yellow solid. Mass spectrum (ion spray): m/z=269 (M+1); 1HNMR (DMSO-d6): 8.57 (s, 1H), 8.29 (d, 1H), 8.03 (s, 1H), 7.55-7.46 (M, 4H), 7.19 (d, 1H), 2.81 (t, 2H), 2.61 (t, 2H).

Sources & evidence

ORD record
ord-37308c3ec06548c090ef40b545fc35d2
Source dataset
uspto-grants-2012_01
Patent number
US08101638B2

Reaction notes

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