Thionyl Chloride → HCID 59750697, compound

HRID 422208Notes

Reaction equation

HRID 422208 reaction equation
O[CH:2]1[CH2:11][CH2:10][CH2:9][C:8]2[CH:7]=[C:6]([O:12][C:13]3[CH:21]=[CH:20][C:16]([C:17]([NH2:19])=[O:18])=[CH:15][N:14]=3)[CH:5]=[CH:4][C:3]1=2.O=S(Cl)[Cl:24]>>[Cl:24][CH:2]1[CH2:11][CH2:10][CH2:9][C:8]2[CH:7]=[C:6]([O:12][C:13]3[CH:21]=[CH:20][C:16]([C:17]([NH2:19])=[O:18])=[CH:15][N:14]=3)[CH:5]=[CH:4][C:3]1=2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 66673152HCID 66673152, compound

Product 1

HCID 59750697HCID 59750697, compound

Procedure

Charge flask with 6-(5-Hydroxy-5,6,7,8-tetrahydro-naphthalen-2-yloxy) nicotinamide (288 mg, 1.01 mmol) and SOCl2 (5 ml) and beat at 50° C. under nitrogen atmosphere with stirring. After 3.5 hours, concentrate on rotary evaporator to give the title compound as a yellow oil. Due to instability, use this material without purification.

Workup

  1. custombeat at 50° C. under nitrogen atmosphere
  2. concentrationconcentrate on rotary evaporator

Sources & evidence

ORD record
ord-41afcb30a1c4440eb8ca09831e168863
Source dataset
uspto-grants-2012_01
Patent number
US08101638B2

Reaction notes

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