反应详情

Furan-2,3-dicarboxylic acid dimethyl ester (1.6 g, 8.69 mmol) is added to EtOH (10 mL) and hydrazine hydrate (1.46 mL, 55% in water). Heat the reaction to reflux for 5-6 h. Cool and concentrate in vacuo to form a slurry. Dilute the material with additional H2O and filter the precipitate. Wash with additional H2O. Transfer material from filter to a round bottom flask and add HCl (7.2 mL, 2N in H2O). Heat reaction mixture to reflux for 4 h. Cool and filter the precipitate washing with H2O, to yield the title compound without further purification (930 mg, 70%)

1. temperatureHeat
2. customthe reaction
3. temperatureto reflux for 5-6 h
4. temperatureCool
5. concentrationconcentrate in vacuo
6. customto form a slurry
7. filtrationfilter the precipitate
8. washWash with additional H2O
9. filtrationTransfer material from filter to a round bottom flask
10. additionadd HCl (7.2 mL, 2N in H2O)
11. temperatureHeat
12. customreaction mixture
13. temperatureto reflux for 4 h
14. temperatureCool
15. filtrationfilter the precipitate
16. washwashing with H2O