2-Bromopyridine → Benzoxazole

HRID 422323Notes

Reaction equation

HRID 422323 reaction equation
BrC1C=CC=CN=1.C([C:12]1[O:13][C:14]2[C:20](C(C)C)=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=1)CC#C>>[O:13]1[C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=[CH:12]1

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 86086819HCID 86086819, compound

Product 1

HCID 9228Benzoxazole

Procedure

The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyridine (41 mg, 0.26 mmol) and 2-(but-3-ynyl)-7-isopropyl-benzo[d]oxazole (55 mg, 0.26 mmol). The crude residue was purified by flash chromatography (DCM/MeOH 99:1) to yield 4.2 mg (14 μmol, 6%) of 7-isopropyl-2-(pyridin-2-yl)but-3-ynyl)benzo[d]oxazole as a red oil.

Workup

  1. customThe crude residue was purified by flash chromatography (DCM/MeOH 99:1)

Sources & evidence

ORD record
ord-902f67e2ae3b4cfd966121d10b3e3149
Source dataset
uspto-grants-2012_01
Patent number
US08101637B2

Reaction notes

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