HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42233Generated: October 25, 2026
Potassium Carbonate → 3-[1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-1H-indole
https://huagongshe.com/reaction/42233
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-(trifluoromethyl)pyridine | HCID 92342 | — |
| Reactant | 3-(4-Piperidinyl)-1H-indole | HCID 702235 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-1H-indole | HCID 4998535 | — |
Reaction Steps
3-piperidin-4-yl-1H-indole (0.5 g, 2.5 mmol) is suspended in 10 ml of DMF and is heated to 60° C. K2CO3 and 5-trifluoromethyl-2-chloropyridine (0.54 g, 3.0 mmol) are added and the reaction mixture is stirred at 95° C. for 1 hour. K2CO3 is removed by filtration and the filtrate is concentrated and purified with a silica gel flash column using heptane and ethyl acetate as the elutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536168B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-8f6ee38d8838478296cd066b6acc8b7a |
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| Source note | uspto-grants-2013_09 |
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