反应详情

温度

60 °C

3-piperidin-4-yl-1H-indole (0.5 g, 2.5 mmol) is suspended in 10 ml of DMF and is heated to 60° C. K2CO3 and 5-trifluoromethyl-2-chloropyridine (0.54 g, 3.0 mmol) are added and the reaction mixture is stirred at 95° C. for 1 hour. K2CO3 is removed by filtration and the filtrate is concentrated and purified with a silica gel flash column using heptane and ethyl acetate as the elutes.

1. customK2CO3 is removed by filtration
2. concentrationthe filtrate is concentrated
3. custompurified with a silica gel flash column