2-Chloro-3-fluoropyridine → HCID 66598099, compound

HRID 422508Notes

Reaction equation

HRID 422508 reaction equation
[C:1]([O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=1)(=[O:6])[CH2:2][CH2:3][C:4]#[CH:5].Cl[C:16]1[C:21]([F:22])=[CH:20][CH:19]=[CH:18][N:17]=1>>[F:22][C:21]1[C:16]([C:5]#[C:4][CH2:3][CH2:2][C:1]([O:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)=[O:6])=[N:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 27827912-Chloro-3-fluoropyridineHCID 86086817HCID 86086817, compound

Product 1

HCID 66598099HCID 66598099, compoundYield 13.1%

Procedure

According to the protocol described in Example 237(B), the reaction between 3-chlorophenyl pent-4-ynoate (580 mg, 2.80 mmol) and 2-chloro-3-fluoropyridine (370 mg, 2.80 mmol) afforded 111 mg of 3-chlorophenyl 5-(3-fluoropyridin-2-yl)pent-4-ynoate (Yield: 13%) as yellow-oil.

Sources & evidence

ORD record
ord-0b23843ff5174258b5f8491e8b469a2c
Source dataset
uspto-grants-2012_01
Patent number
US08101637B2

Reaction notes

Loading…