反应详情

The title compound was prepared in accordance with the general method of Example 1, from 2-iodopyridine (453 mg, 2.21 mmol) and 2-(but-3-ynyl)isoindoline-1,3-dione (400 mg, 2.01 mmol, Example 189(B)). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 70:30) to yield 250 mg (0.90 mmol, 45%) of 2-(4-pyridin-2-yl)but-3-ynyl)isoindoline-1,3-dione as.

1. customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 70:30)