反应详情

温度

50 °C

A solution of methyl 4-methyl-3-(1-(1,1,1-trifluoropropan-2-yl)phthalazin-6-yl)benzoate (91 mg, 243 μmol) in THF (1200 μl) and methanol (600 μl) was added NAOH (1N aqueous solution; 1215 μl, 1215 μmol) and stirred at 50° C. for 2 h, during which LC-MS indicated completion of reaction. After concentrating in vacuo, the slurry was diluted with water and the pH was adjusted with 10% aqueous HCl solution to ˜7, resulting in the precipitation of 4-methyl-3-(1-(1,1,1-trifluoropropan-2-yl)phthalazin-6-yl)benzoic acid (86 mg, 98% yield) as a yellow solid. MS (ES+): 361.2 (M+H)+.

1. customcompletion of reaction
2. concentrationAfter concentrating in vacuo
3. additionthe slurry was diluted with water