2-Chloro-5-methylphenol → 2-(5-Chloro-2-methyl-4-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

HRID 422562Notes

Reaction equation

HRID 422562 reaction equation
F[C:2]1[C:3]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:4][C:5]([CH3:17])=[C:6]([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]2)[CH:7]=1.[Cl:22]C1C=CC(C)=CC=1O>>[Cl:22][C:2]1[C:3]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:4][C:5]([CH3:17])=[C:6]([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]2)[CH:7]=1

Participants

3

Reactant 2

HCID 120082-Chloro-5-methylphenolHCID 666747872-(5-Fluoro-2-methyl-4-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 666746652-(5-Chloro-2-methyl-4-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Procedure

The title compound was prepared by a method analogous to that described for 2-(5-fluoro-2-methyl-4-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Steps 1-5 of Example 223), using 2-chloro-5-methylphenol as the starting material. MS (ESI, pos. ion) m/z: 353.0 (M+Na).

Sources & evidence

ORD record
ord-719d900b2f77401eaa5415f8eac93a7f
Source dataset
uspto-grants-2012_01
Patent number
US08101612B2

Reaction notes

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