4-(2-(4-amino-3-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N-(3-(2-(dimethylamino)ethyl)phenyl)pyrimidin-2-amine → 4-(3-(2-(3-(2-(Dimethylamino)ethyl)phenylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzene-1,2-diamine

Participants

Reaction Steps

A 50 mL pressure bottle was charged with 4-(2-(4-amino-3-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N-(3-(2-(dimethylamino)ethyl)phenyl)pyrimidin-2-amine (60 mg, 0.121 mmol) from EXAMPLE 10A and tetrahydrofuran (20 mL). The solution was treated with 50% palladium on carbon (30.0 mg, 0.282 mmol) and stirred for 24 hours at 30 psi at ambient temperature. The mixture was filtered through a nylon membrane and solvents were concentrated to provide the title compound. MS (ESI+) m/e 465.1 (M+H)+.

Provenance & Evidence