反应详情

A 50 mL pressure bottle was charged with 4-(2-(4-amino-3-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N-(3-(2-(dimethylamino)ethyl)phenyl)pyrimidin-2-amine (60 mg, 0.121 mmol) from EXAMPLE 10A and tetrahydrofuran (20 mL). The solution was treated with 50% palladium on carbon (30.0 mg, 0.282 mmol) and stirred for 24 hours at 30 psi at ambient temperature. The mixture was filtered through a nylon membrane and solvents were concentrated to provide the title compound. MS (ESI+) m/e 465.1 (M+H)+.

1. filtrationThe mixture was filtered through a nylon membrane and solvents
2. concentrationwere concentrated