反应详情

To a solution of EXAMPLE 59A (1.3 g, 5 mmole) and diisopropyl-ethyl amine (1.3 mL, 7.5 mmole) in dichloromethane (20 mL) at ambient temperature was added 2-(trimethylsilyl)ethoxymethyl chloride (1.25 g, 7.5 mmole) dropwise. The solution was stirred overnight. Brine (20 mL) was added and the mixture was extracted with ethyl acetate. The mixture was dried with magnesium sulfate, filtered and concentrated. The residue was purified on a silica gel column eluting with 25% ethyl acetate in hexane. The two regioisomers were isolated as a mixture. MS (DCI) m/e 397 (M+H)+.

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe mixture was dried with magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was purified on a silica gel column
6. washeluting with 25% ethyl acetate in hexane
7. customThe two regioisomers were isolated as a mixture