Hydrazine hydrate (1:1) → 3-Indolepropionic acid hydrazide

HRID 422834노트

반응식

HRID 422834 반응식
C([O:3][C:4](=O)[CH2:5][CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][CH:8]=1)C.O.[NH2:18][NH2:19]>C(O)C>[NH:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([CH2:6][CH2:5][C:4]([NH:18][NH2:19])=[O:3])=[CH:8]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 225390Ethyl 3-(1h-indol-3-yl)propanoate

생성물 1

HCID 2305803-Indolepropionic acid hydrazide수율 98%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3-(1H-Indol-3-yl)-propionic acid ethyl ester (4.30 g, 1 eq) and hydrazine hydrate (˜9.6 ml, 10 eq) in ethanol (70 ml) is heated at 60° C. overnight. The reaction mixture is concentrated under reduced pressure and diluted with methylene chloride. The new organic solution is washed with water, dried over MgSO4, filtered and evaporated to dryness, to afford the title compound as white solid (3.9 g, 98% yield), which is used as such for the next step.

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. additiondiluted with methylene chloride
  3. washThe new organic solution is washed with water
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-14013f02603e48cd9cdf138b5dea52dd
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101649B2

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