Phenol → HCID 25267396, compound

HRID 422884Notes

Reaction equation

C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]23[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH:19]2[O:18][C:17]2[CH:25]=[CH:26][C:27]([F:29])=[CH:28][C:16]3=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.C1(O)C=CC=CC=1>>[F:29][C:27]1[CH:26]=[CH:25][C:17]2[O:18][CH:19]3[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:15]3([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)[C:16]=2[CH:28]=1

Participants

Reactant 2

HCID 996Phenol

HCID 57701076HCID 57701076, compound

Product 1

HCID 25267396HCID 25267396, compound

Procedure

The title compound 448 was synthesized starting from compound 32 using the procedure F as described for the synthesis of phenol 807. 1H-NMR (400 MHz, CDCl3): δ ppm 7.18-7.07 (m, 2H), 6.82 (dt, J=8.79, 8.79, 2.75 Hz, 1H), 6.78-6.69 (m, 3H), 6.62 (dd, J=8.20, 2.73 Hz, 1H), 5.08 (broad s, 1H), 4.91 (dd, J=7.30, 1.61 Hz, 1H), 2.45-2.26 (m, 1H), 2.23-1.95 (m, 2H), 1.82 (tdd, J=14.57, 12.67, 1.56, 1.56 Hz, 1H), 1.77-1.48 (m, 4H), 1.44-1.03 (m, 2H).

Sources & evidence

ORD record: ord-6df5ce4f8c184fb78bba82d816521ca2
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08101651B2

Reaction notes

Loading…