HCID 57701070, compound → HCID 25267399, compound

HRID 422886Notes

Reaction equation

HRID 422886 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]23[CH2:27][CH2:26][CH2:25][CH2:24][CH:16]2[O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=23)=[CH:11][CH:10]=1)C1C=CC=CC=1.FC1C=CC=CC=1C1(C2C=CC(O)=CC=2)CCCCCC1=O>>[CH:20]1[C:19]2[C:15]3([C:12]4[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=4)[CH2:27][CH2:26][CH2:25][CH2:24][CH:16]3[O:17][C:18]=2[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 57701070HCID 57701070, compoundHCID 57701091HCID 57701091, compound

Product 1

HCID 25267399HCID 25267399, compound

Procedure

The title compound 961 was synthesized from compound 34 (10 mg) using the procedure described for the synthesis of compound 20. Purity LC MS/UV: m/z=265 (M−1) was confirmed. Yield: 7 mg (93%). 1H-NMR (400 MHz, CDCl3): δ ppm 7.26-7.20 (m, 2H), 7.17-7.11 (m, 1H), 6.87-6.84 (m, 3H), 6.80-6.77 (m, 2H), 4.83 (t, J=4.29, 4.29 Hz, 1H), 4.67 (s, 1H), 2.35-2.22 (m, 1H), 2.05-1.96 (m, 1H), 1.86-1.50 (m, 6H).

Sources & evidence

ORD record
ord-fd4d104eb5844e268a1a6d4c293b9821
Source dataset
uspto-grants-2012_01
Patent number
US08101651B2

Reaction notes

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