Hydrochloric Acid → Ivabradine Hydrochloride

HRID 423133Notes

Reaction equation

[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C@@H:8]([CH2:14][N:15]([CH3:35])[CH2:16][CH2:17][CH2:18][N:19]1[C:25](=[O:26])[CH2:24][C:23]3[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:22]=3[CH2:21][CH2:20]1)[CH2:7]2>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C@@H:8]([CH2:14][N:15]([CH3:35])[CH2:16][CH2:17][CH2:18][N:19]1[C:25](=[O:26])[CH2:24][C:23]3[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:22]=3[CH2:21][CH2:20]1)[CH2:7]2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 132999Ivabradine

Product 1

HCID 3045381Ivabradine Hydrochloride

Procedure

The hydrochloride of the product obtained in Example 3, Step 2, is prepared by following the procedure described in patent specification EP 0 534 859 (Example 2, Step E).

Sources & evidence

ORD record: ord-b11b1124e18e4b138e063712e493f2f2
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08101747B2

Reaction notes

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