Toluene → HCID 66674890, compound

Participants

Reaction Steps

0.1 g of 4,5-difluoro-6-(2-pentynyloxy)pyrimidine and 0.05 g of piperidine were added to 0.2 ml of toluene, then the reaction mixture was stirred at room temperature for 3 hours. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.12 g of 5-fluoro-4-(2-pentynyloxy)-6-piperidinopyridine (referred as the present compound (6) hereinafter).

Provenance & Evidence