Toluene → HCID 66674890, compound

HRID 423163Notes

Reaction equation

HRID 423163 reaction equation
F[C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14])N=[CH:4][N:3]=1.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.[C:21]1(C)C=CC=CC=1>>[F:8][C:7]1[C:6]([O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14])=[CH:21][CH:4]=[N:3][C:2]=1[N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 8082PiperidineHCID 596619684,5-Difluoro-6-(2-pentynyloxy)pyrimidine

Product 1

HCID 66674890HCID 66674890, compound

Procedure

0.1 g of 4,5-difluoro-6-(2-pentynyloxy)pyrimidine and 0.05 g of piperidine were added to 0.2 ml of toluene, then the reaction mixture was stirred at room temperature for 3 hours. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.12 g of 5-fluoro-4-(2-pentynyloxy)-6-piperidinopyridine (referred as the present compound (6) hereinafter).

Sources & evidence

ORD record
ord-c29e394319ca4dd696c714711cfb396d
Source dataset
uspto-grants-2012_01
Patent number
US08101753B2

Reaction notes

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