反应详情

温度

160 °C

10 g of 3,3-dimethyl succinic acid and 102.7 g of urea were mixed and stirred at 160° C. for 10 hours. Then water was added to the reaction mixture which was cooled to about 100° C., and further cooled to about room temperature, then extracted with ethyl acetated three times. The organic layers were joined, washed with saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.8 g of 3,3-dimethyl-2,5-pyrrolidine dion.

1. temperaturewas cooled to about 100° C.
2. temperaturefurther cooled to about room temperature
3. extractionextracted with ethyl
4. washwashed with saturated aqueous solution of sodium chloride
5. dry with materialdried with anhydrous magnesium sulfate
6. concentrationconcentrated