HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 423250Generated: October 30, 2026
Methyl iodide → 4-Hydroxyisophthalic acid 1-ethyl ester 3-methyl ester
https://huagongshe.com/reaction/423250
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-(Ethoxycarbonyl)-2-hydroxybenzoic acid | HCID 53959762 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Hydroxyisophthalic acid 1-ethyl ester 3-methyl ester | HCID 58629736 | 87.3% |
Reaction Steps
To a solution of 4-hydroxyisophthalic acid 1-ethyl ester (4.51 g) in DMF (36 mL) were added methyl iodide (3.66 g) and sodium hydrogen carbonate (2.16 g). The mixture was stirred at 60° C. for 2 hours and then allowed to stand for cooling down to room temperature. The resulting precipitated solid formed upon addition of water was filtered off to give the title compound (4.20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08101774B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-d8b241858f8e42eca531cd47128c03fc |
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| Source note | uspto-grants-2012_01 |
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