反应详情

温度

60 °C

To a solution of 4-hydroxyisophthalic acid 1-ethyl ester (4.51 g) in DMF (36 mL) were added methyl iodide (3.66 g) and sodium hydrogen carbonate (2.16 g). The mixture was stirred at 60° C. for 2 hours and then allowed to stand for cooling down to room temperature. The resulting precipitated solid formed upon addition of water was filtered off to give the title compound (4.20 g).

1. temperaturefor cooling down to room temperature
2. customThe resulting precipitated solid
3. customformed upon addition of water
4. filtrationwas filtered off