反应详情

To a solution of 4-hydroxyisophthalic acid (16.0 g) in methanol (150 mL) was added conc. sulfuric acid (5 mL), and the mixture was heated for 22 hours under reflux. Then, the reaction solution was allowed to stand for cooling down to room temperature, diluted with water (150 mL), and added with sodium bicarbonate (15 g). The resulting precipitate was filtered, washed successively with water/methanol (1:1, v/v) (150 mL) and water, and dried to give the title compound (17.45 g).

1. temperaturethe mixture was heated for 22 hours
2. temperatureunder reflux
3. filtrationThe resulting precipitate was filtered
4. washwashed successively with water/methanol (1:1
5. dry with materialv/v) (150 mL) and water, and dried