HRID423275

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15908

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

C8H17N3

HCID3692407

未命名化合物

结构：Cc1noc(-c2ccc(OC(=O)CCCc3ccc(NC(=O)c4ccccc4-c4ccc(C(F)(F)F)cc4)c(C(=O)N(C)C)c3)cc2)n1

HCID11628884

未命名化合物

结构：CN(C)C(=O)c1cc(CCCC(=O)O)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1

HCID66676366

未命名化合物

PRODUCTS

生成物

结构：CCC(C(=O)Oc1ccc(-c2nc(C)no2)cc1)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)c(C(=O)N(C)C)c1

HCID131729408

未命名化合物

PROCEDURE

实验过程

4-(3-Methyl-[1,2,4]oxadiazol-5-yl)phenol (64 mg) and 4-{3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}butanoic acid (200 mg)(synthesized separately in a similar manner to Working Example 1-1) were treated (WSC condensation) in a similar manner to Step g) of Working Example 1-1 to give the title compound (Compound 1-2) (112 mg).

WORKUP

后处理

additionwere treated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fcd7558291c34305afa4e31714576790
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08101774B2
来源说明: uspto-grants-2012_01

反应 SMILES

CC1N=C(C2C=CC(O)=CC=2)ON=1.[CH3:14][N:15]([CH3:49])[C:16]([C:18]1[CH:19]=[C:20](CCCC(O)=O)[CH:21]=[CH:22][C:23]=1[NH:24][C:25]([C:27]1[C:28]([C:33]2[CH:38]=[CH:37][C:36]([C:39]([F:42])([F:41])[F:40])=[CH:35][CH:34]=2)=[CH:29][CH:30]=[CH:31][CH:32]=1)=[O:26])=[O:17].CCN=C=NCCCN(C)C.[CH3:61][C:62]1[N:66]=[C:65]([C:67]2[CH:72]=[CH:71][C:70]([O:73][C:74](=[O:108])[CH2:75][CH2:76][CH2:77]C3C=CC(NC(C4C(C5C=CC(C(F)(F)F)=CC=5)=CC=CC=4)=O)=C(C(=O)N(C)C)C=3)=[CH:69][CH:68]=2)[O:64][N:63]=1>>[CH3:61][C:62]1[N:66]=[C:65]([C:67]2[CH:72]=[CH:71][C:70]([O:73][C:74](=[O:108])[CH:75]([C:20]3[CH:21]=[CH:22][C:23]([NH:24][C:25]([C:27]4[C:28]([C:33]5[CH:38]=[CH:37][C:36]([C:39]([F:42])([F:40])[F:41])=[CH:35][CH:34]=5)=[CH:29][CH:30]=[CH:31][CH:32]=4)=[O:26])=[C:18]([C:16](=[O:17])[N:15]([CH3:14])[CH3:49])[CH:19]=3)[CH2:76][CH3:77])=[CH:69][CH:68]=2)[O:64][N:63]=1