反应详情

E1 (30 mg) was dissolved in EtOAc (1 ml), treated with 2M aqueous NaOH (40 ul), diluted with H2O (1 ml) and extracted with EtOAc (3×5 ml), using a small volume of brine during the third extraction to aid phase separation. The combined organics were evaporated to give the title compound (37 mg) as a green solid. δH (methanol-d4, 400 MHz): 2.68 (2H, t), 4.48 (2H, t), 6.55 (1H, d), 7.49 (1H, d), 7.45-7.56 (5H, m), 7.62 (1H, d), 7.92 (1H, d), 8.03 (1H, s), 8.35 (1H, s). MS (ES+): C24H16F3N3O3S requires 483; found 484 (MH+).

1. extractionextracted with EtOAc (3×5 ml)
2. extractionduring the third extraction
3. customphase separation
4. customThe combined organics were evaporated