反应详情

To a solution of 4-(bromomethyl)-N-tert-butyl-2-fluorobenzenesulfonamide (500 mg) in THF/MeOH (1:1, 15 ml) was added NH4OH (4.5 ml). The mixture was stirred at room temperature overnight. The reaction mixture was concentrated and partitioned between EtOAc/H2O and the aq phase was extracted by EtOAc (3×). The organic phase was then combined, washed with brine, dried over Na2SO4 and concentrated to give 4-(aminomethyl)-N-tert-butyl-2-fluorobenzenesulfonamide as a viscous oil, which was used in the next step without further purification.

1. concentrationThe reaction mixture was concentrated
2. custompartitioned between EtOAc/H2O
3. extractionthe aq phase was extracted by EtOAc (3×)
4. washwashed with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated