Hydrochloric Acid → HCID 131729410, compound

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Reaction Steps

Add 4-{5-[2-(4-chloro-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-pyridin-2-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (5.41 g, 10.02 mmol) to a solution of 1:1 MeOH:dichloromethane (80 mL). Then add 4M HCl in dioxane (18.53 mL, 74 mmol) and stir at RT overnight. Filter the reaction and wash with dichloromethane. Dry thoroughly to yield the title compound quantitatively. MS/ES m/z (35Cl) 440.0 [M+H]+.

Provenance & Evidence