Hydrochloric Acid → HCID 131729410, compound

HRID 423421Notes

Reaction equation

HRID 423421 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:26][CH2:25][C:24]4[CH:27]=[C:28]([C:30]5[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=5)[S:29][C:23]=4[C:22]3=[O:37])=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.CO.Cl.O1CCOCC1>ClCCl>[ClH:36].[Cl:36][C:33]1[CH:32]=[CH:31][C:30]([C:28]2[S:29][C:23]3[C:22](=[O:37])[N:21]([C:18]4[CH:17]=[N:16][C:15]([O:14][CH:11]5[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]5)=[CH:20][CH:19]=4)[CH2:26][CH2:25][C:24]=3[CH:27]=2)=[CH:35][CH:34]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 312751,4-DioxaneHCID 66673876HCID 66673876, compound

Product 1

HCID 131729410HCID 131729410, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Add 4-{5-[2-(4-chloro-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-pyridin-2-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (5.41 g, 10.02 mmol) to a solution of 1:1 MeOH:dichloromethane (80 mL). Then add 4M HCl in dioxane (18.53 mL, 74 mmol) and stir at RT overnight. Filter the reaction and wash with dichloromethane. Dry thoroughly to yield the title compound quantitatively. MS/ES m/z (35Cl) 440.0 [M+H]+.

Workup

  1. filtrationFilter
  2. customthe reaction
  3. washwash with dichloromethane
  4. customDry thoroughly

Sources & evidence

ORD record
ord-27943eff24ca48fd88848eae6b271c87
Source dataset
uspto-grants-2012_01
Patent number
US08101764B2

Reaction notes

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