HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-[6-((r)-3-Amino-pyrrolidin-1-yl)-pyridin-3-yl]-2-(4-chloro-phenyl)-6h-thieno[2,3-c]pyridin-7-one, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 6-[6-((R)-3-amino-pyrrolidin-1-yl)-pyridin-3-yl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one | HCID 24758102 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-[6-((r)-3-Amino-pyrrolidin-1-yl)-pyridin-3-yl]-2-(4-chloro-phenyl)-6h-thieno[2,3-c]pyridin-7-one, hydrochloride | HCID 24758101 | 93% |
Reaction Steps
Prepare the HCl salt by dissolving the free base in MeOH and CH2Cl2 then adding 1N HCl in EtOH and evaporating. Suspend the salt in Et2O and filter to give 0.386 g (93%) of the title compound. MS/ES m/z (35Cl) 423.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101764B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-aabb87edc62f46e181d8303ea79d0fcb |
| Source note | uspto-grants-2012_01 |