HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Ethylsulphonyl)benzeneboronic acid → 1-Methylethyl 4-({[4'-(ethylsulfonyl)-4-biphenylyl]oxy}methyl)-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Ethylsulphonyl)benzeneboronic acid | HCID 2773420 | — |
| Reactant | 4-(4-Bromophenoxymethyl)piperidine-1-carboxylic acid isopropyl ester | HCID 57930300 | — |
| Product | 1-Methylethyl 4-({[4'-(ethylsulfonyl)-4-biphenylyl]oxy}methyl)-1-piperidinecarboxylate | HCID 59177764 | 20% |
Reaction Steps
The title compound (8.9 mg, 20%) was prepared from [4-(ethylsulfonyl)phenyl]boronic acid (21.4 mg, 0.1 mmol) and 1-methylethyl 4-{[(4-bromophenyl)oxy]methyl}-1-piperidinecarboxylate (Example 9, Step 2, 36 mg, 0.10 mmol) in a manner similar to Example 9, Step 3. LRMS (ESI), m/z 446 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101634B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-094634c8ca634db5aa1ef0e42a638e23 |
| Source note | uspto-grants-2012_01 |