反应详情

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (4.08 g, 18.3 mmol) was suspended in 1 N HCl(aq) (150 mL) and stirred at reflux for 3.5 h. The solution was concentrated in vacuo and the residue was triturated with acetone. The filtrate was collected, concentrated, and the residue triturated with diethyl ether to afford 2.67 g (91%) of 1-(trifluoromethyl)cyclopropylamine hydrochloride as a white solid.

1. temperatureat reflux for 3.5 h
2. concentrationThe solution was concentrated in vacuo
3. customthe residue was triturated with acetone
4. customThe filtrate was collected
5. concentrationconcentrated
6. customthe residue triturated with diethyl ether