3-Bromo-5-(trifluoromethyl)benzenesulfonyl chloride → 3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide

HRID 42363Notes

Reaction equation

HRID 42363 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6](F)=[C:7]([S:9]([NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])(=[O:11])=[O:10])[CH:8]=1.BrC1C=C(S(Cl)(=O)=O)C=C([C:25]([F:28])([F:27])[F:26])C=1>>[NH2:1][CH2:2][C:3]1[CH:8]=[C:7]([S:9]([NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])(=[O:11])=[O:10])[CH:6]=[C:5]([C:25]([F:28])([F:27])[F:26])[CH:4]=1

Participants

3

Reactant 2

HCID 27786103-Bromo-5-(trifluoromethyl)benzenesulfonyl chlorideHCID 287163695-Aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide

Product 1

HCID 671611623-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide

Procedure

3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide was synthesized in a manner analogous to 5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide in Example 3, using 3-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride in place of 5-chloro-2-fluorobenzene-1-sulfonyl chloride.

Sources & evidence

ORD record
ord-3d5058b4f7644799a83183f49e5ee90b
Source dataset
uspto-grants-2013_09
Patent number
US08536187B2

Reaction notes

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