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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42363Generated: October 29, 2026

3-Bromo-5-(trifluoromethyl)benzenesulfonyl chloride → 3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide

https://huagongshe.com/reaction/42363

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromo-5-(trifluoromethyl)benzenesulfonyl chlorideHCID 2778610—
Reactant5-Aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamideHCID 28716369—
Product3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamideHCID 67161162—

Reaction Steps

3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide was synthesized in a manner analogous to 5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide in Example 3, using 3-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride in place of 5-chloro-2-fluorobenzene-1-sulfonyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536187B2
Source datasetuspto-grants-2013_09
ORD IDord-3d5058b4f7644799a83183f49e5ee90b
Source noteuspto-grants-2013_09