反应详情

1-Methylethyl 4-[({6-[2-fluoro-4-(methylthio)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate (0.16 g, 55%) was prepared as a light yellow solid from [2-fluoro-4-(methylthio)phenyl]boronic acid (prepared as in Example 161, Alternative synthesis, Step 2, 0.26 g, 1.4 mmol), 1-methylethyl 4-{[(6-bromo-3-pyridinyl)oxy]methyl}-1-piperidinecarboxylate (prepared as in Example 81, Step 1, 0.25 g, 0.7 mmol), Na2CO3 (0.148 g, 1.4 mmol), Pd(PPh3)2Cl2 (49 mg, 0.07 mmol), water (1 mL) and DME (2 mL) in a manner similar to Example 21, Step 3. LRMS (APCI), m/z 419 (M+H).