HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 66673094, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | [2-Fluoro-4-(methylsulfanyl)phenyl]boronic acid | HCID 44717667 | — |
| Reactant | 4-(6-Bromopyridin-3-yloxymethyl)piperidine-1-carboxylic acid isopropyl ester | HCID 86638737 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 66673094 | HCID 66673094 | 55% |
Reaction Steps
1-Methylethyl 4-[({6-[2-fluoro-4-(methylthio)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate (0.16 g, 55%) was prepared as a light yellow solid from [2-fluoro-4-(methylthio)phenyl]boronic acid (prepared as in Example 161, Alternative synthesis, Step 2, 0.26 g, 1.4 mmol), 1-methylethyl 4-{[(6-bromo-3-pyridinyl)oxy]methyl}-1-piperidinecarboxylate (prepared as in Example 81, Step 1, 0.25 g, 0.7 mmol), Na2CO3 (0.148 g, 1.4 mmol), Pd(PPh3)2Cl2 (49 mg, 0.07 mmol), water (1 mL) and DME (2 mL) in a manner similar to Example 21, Step 3. LRMS (APCI), m/z 419 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101634B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-572af1249c9c46c7a52a6a69ffb0aec3 |
| Source note | uspto-grants-2012_01 |