N'-(6-oxo-7-phenyl-5,6-dihydro-1,5-naphthyridin-2-yl)propanohydrazide → HCID 67093792, compound

HRID 42374Notes

Reaction equation

[O:1]=[C:2]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][C:9]2[N:8]=[C:7]([NH:18][NH:19][C:20](=O)[CH2:21][CH3:22])[CH:6]=[CH:5][C:4]=2[NH:3]1>CC(O)=O>[CH2:21]([C:20]1[N:8]2[C:9]3[CH:10]=[C:11]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[C:2](=[O:1])[NH:3][C:4]=3[CH:5]=[CH:6][C:7]2=[N:18][N:19]=1)[CH3:22]

Participants

Conditions

Temperature: 180 °C

Procedure

A mixture of N′-(6-oxo-7-phenyl-5,6-dihydro-1,5-naphthyridin-2-yl)propanohydrazide (7-3) (70 mg, 0.227 mmol) in AcOH (5 mL) was heated under microwave irradiation at 180° C. for 15 minutes. The solvent was removed under reduced pressure to give 1-ethyl-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7(6H)-one (7-4) as pale yellow solid.

Workup

customThe solvent was removed under reduced pressure

Sources & evidence

ORD record: ord-e9822ebf9b684921a07ed6fcd74abb35
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08536193B2

Reaction notes

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