Phosphorus oxychloride → HCID 58216599, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-ethyl-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7(6H)-one (7-4) (70 mg, 0.241 mmol) and POCl3 (3.0 mL, 32.2 mmol) in acetonitrile (2 mL) was heated under microwave irradiation at 150° C. for 1.5 hours. The solvent was removed under reduced pressure, and the residue was diluted with CHCl3, washed with sat. NaHCO3 solution, dried (MgSO4), filtered, and the solvent was removed under reduced pressure to give 7-chloro-1-ethyl-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridine (7-5) as pale yellow solid.

Provenance & Evidence