反应详情

温度

150 °C

A mixture of 1-ethyl-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7(6H)-one (7-4) (70 mg, 0.241 mmol) and POCl3 (3.0 mL, 32.2 mmol) in acetonitrile (2 mL) was heated under microwave irradiation at 150° C. for 1.5 hours. The solvent was removed under reduced pressure, and the residue was diluted with CHCl3, washed with sat. NaHCO3 solution, dried (MgSO4), filtered, and the solvent was removed under reduced pressure to give 7-chloro-1-ethyl-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridine (7-5) as pale yellow solid.

1. customThe solvent was removed under reduced pressure
2. additionthe residue was diluted with CHCl3
3. washwashed with sat. NaHCO3 solution
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customthe solvent was removed under reduced pressure