反应详情

A solution of 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one (35 g, 0.2 mol) in THF (100 mL) was added dropwise to a suspension of LiAlH4 (18 g, 0.47 mol) in THF (200 mL) at 0° C. After addition, the mixture was stirred at room temperature for 30 min and then slowly heated to reflux for 1 h. The mixture was then cooled to 0° C. Water (18 mL) and NaOH solution (10%, 100 mL) were carefully added to quench the reaction. The solid was filtered off and the filtrate was concentrated to give 4,4-dimethyl-1,2,3,4-tetrahydro-quinoline.

1. additionAfter addition
2. temperatureslowly heated
3. temperatureto reflux for 1 h
4. temperatureThe mixture was then cooled to 0° C
5. customto quench
6. customthe reaction
7. filtrationThe solid was filtered off
8. concentrationthe filtrate was concentrated